How should Dilantin (Phenytoin) 100 mg I.V.P.B. be administered?

Dilantin (Phenytoin) should be administered with 50 ml of 0.9% NaCl because it is crucial for maintaining the medication's stability and effectiveness. Phenytoin is incompatible with dextrose solutions and can precipitate when mixed with D5W (5% dextrose in water). Using sterile water is not appropriate, as it can lead to dilution issues that may affect the absorption and efficacy of the drug. Furthermore, while normal saline is often utilized in IV therapy, administering Dilantin specifically with 10 ml of normal saline may not be adequate to ensure proper dilution and compatibility, which is why 50 ml of 0.9% NaCl is the preferred option. This method helps ensure that the medication is delivered safely and effectively, minimizing the risk of adverse reactions.